L-type calcium channel targeting and local signalling in cardiac myocytes
نویسندگان
چکیده
منابع مشابه
L-type calcium channel targeting and local signalling in cardiac myocytes.
In the heart, Ca(2+) influx via Ca(V)1.2 L-type calcium channels (LTCCs) is a multi-functional signal that triggers muscle contraction, controls action potential duration, and regulates gene expression. The use of LTCC Ca(2+) as a multi-dimensional signalling molecule in the heart is complicated by several aspects of cardiac physiology. Cytosolic Ca(2+) continuously cycles between ~100 nM and ~...
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The Open University's repository of research publications and other research outputs Atrial myocytes demonstrate the diversity of cardiac calcium signalling Journal Article Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult t...
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BACKGROUND Tramadol is a centrally acting analgesic, whose mechanism of action involves opioid-receptor activation. Previously, we have shown that tramadol and its enantiomers had a negative inotropic effect on the papillary muscle in which the (+)-enantiomer is more potent than (-)- and (±)-tramadol. OBJECTIVE In this study, we investigated the effects of tramadol and its enantiomers on L-ty...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2013
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvt021